How can researchers see inside a living mouse without surgery? A common method involves a small animal in vivo imaging system that uses micro-computed tomography, or micro-CT. This technology provides detailed, three-dimensional views of anatomical structures, making it a powerful tool for in vivo imaging in preclinical studies. BPLabLine offers such systems, which are designed for non-invasive visualization in laboratory research.
The Principle of X-Ray Imaging
At its core, a micro-CT scanner functions similarly to a medical CT scanner but on a smaller, high-resolution scale. The system generates a series of X-rays that pass through the anesthetized animal. Dense tissues, like bone, absorb more X-rays than soft tissues. A digital detector on the opposite side captures the varying intensities of the transmitted X-rays, creating a two-dimensional projection image.
Creating a 3D Model through Reconstruction
The key to the three-dimensional output is movement. The small animal in vivo imaging system rotates the animal step-by-step, capturing a large number of these 2D projections from different angles. Sophisticated computer software then processes all these individual images. Using mathematical algorithms, it reconstructs a high-resolution 3D volumetric model of the animal’s internal anatomy.
Applications in Longitudinal Research
This non-destructive nature is what makes micro-CT so valuable for in vivo imaging. Scientists can monitor disease progression, such as bone loss or tumor development, in the same animal over time. This reduces the number of animals needed for a study and provides robust, longitudinal data. The precision and reproducibility of these systems are critical for generating consistent results.
The detailed anatomical data produced by a small animal in vivo imaging system like micro-CT supports a wide range of research, from oncology to bone disease. BPLabLine provides these advanced imaging tools as part of its commitment to empowering scientific discovery, allowing researchers to observe internal processes with clarity and confidence.
